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Brain systems and behaviors underlying response to obesity treatment in children-(BASIC2)
BASIC2
What is the goal of the study?
This is a drug study that will examine how the combination of family-based behavioral treatment (FBT) and a glucagon-like peptide-1 receptor agonist (GLP-1RA) drug intervention affects health outcomes in obese children from 10-12 years old. Participation includes a double-blinded 24 week period where participants receive either placebo or active drug and a 1-year follow-up period. Health outcomes will be evaluated by measuring changes to (a) BMI z-score, (b) neural activation by food cues & (c) mediobasal hypothalamus gliosis (via fMRI & sMRI).
Who can participate in the study?
Everyone