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A Phase II Randomized Controlled Trial Comparing GVHD-Reduction Strategies for Allogeneic Peripheral Blood Transplantation (PBSCT) for Patients with Acute Leukemia or Myelodysplastic Syndrome: Selective Depletion of CD45RA+ Naïve T Cells (TND) vs. Post-Transplantation Cyclophosphamide (PTCy)

9749 GVHD Reduction Strategies

  • Condition(s): BMT
  • Phase: II
  • Clinicaltrials.gov ID: NCT03970096

What is the goal of the study?

This Phase II prospective trial will compare PBSCT with (Arm A) TND, tacrolimus and methotrexate to (Arm C) PTCy for the treatment of patients with high-risk acute leukemia or MDS who require HCT for consolidation of remission.

Who can participate in the study?

Everyone

Study Team: