A boy plays on a skateboard in from of a Cares Foundation table

Endocrinology Research

At Seattle Children’s, our research team partners with families to find new and better ways to care for kids and teens with endocrine conditions.

Our studies look at:

  • How to help kids grow with new treatments for short stature and growth hormone needs
  • Better care for complex conditions like congenital adrenal hyperplasia (CAH) and Prader-Willi syndrome
  • How treatments for low or missing hormones support puberty and development
  • Ways to support healthy weight and metabolism as kids grow

When families join a study, they help us learn. We are proud to work together with families and community partners, so every child can look forward to a healthier future.

Clinical Trials and Research Studies

Growth/Short stature

Clinical Trial / Research Study

A US Multi-center, Prospective, Non-interventional, Long-term, Effectiveness and Safety Study of Patients Treated with SKYTROFA (lonapegsomatropin-tcgd) (SkybriGHt)

This prospective, non-interventional, long-term, safety and effectiveness study of patients treated with SKYTROFA (lonapegsomatropin) will seek to further assess the clinical outcomes of...

Clinicaltrials.gov ID: NCT05820672

Clinical Trial / Research Study

SkyPASS: A prospective, non-interventional (NIS), long-term, post-authorisation safety study (PASS) of patients treated with lonapegsomatropin.

This prospective, non-interventional, long-term, post-authorisation safety study of patients treated with lonapegsomatropin will seek to further assess the important potential risks (neoplasms,...

Clinicaltrials.gov ID: NCT05775523

Clinical Trial / Research Study

A Phase 2, Randomized, Controlled, Multicenter Study of Vosoritide in Children With Idiopathic Short Stature

Study 111-210 is a Phase 2, randomized, multicenter study of vosoritide in children with Idiopathic Short Stature (ISS) who are naïve to growth hormone treatment, intended to characterize the...

Clinicaltrials.gov ID: NCT06382155

Delayed puberty

Clinical Trial / Research Study

An Open-Label Multiple-Dose, 52-Week Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents (ages: 12 to <18 years) with Conditions Associated with Deficiency or Absence of Endogenous Testosterone Due to Primary or Secondary Hypogonadism (Congenital or Acquired)

The objectives of this study are: • To determine the efficacy of XYOSTED administered at an appropriate dose and interval to permanently hypogonadal adolescent males. • To determine the safety and...

Clinicaltrials.gov ID: NCT06689085

Metabolism, weight regulation and hypothalamic obesity

Clinical Trial / Research Study

The Effects of Tirzepatide in Young adults with Prader-Willi Syndrome, Hypothalamic Obesity and General Non-Syndromic Obesity

To evaluate the percent change in weight and BMI from baseline during 48 weeks of treatment with tirzepatide in young adults with Prader-Willi Syndrome (PWS), hypothalamic obesity (HO), general...

Clinicaltrials.gov ID: NCT06901245

Clinical Trial / Research Study

Efficacy and Safety of Phentermine/Topiramate in Youth and Young Adults with Hypothalamic Obesity

The purpose of this study is to evaluate how safe and effective the drug Qsymia (Phentermine/Topiramate or Ph/T) is for children, adolescents, and young adults with hypothalamic obesity. We will also...

Clinicaltrials.gov ID: NCT06299891

Registries

Clinical Trial / Research Study

PWS-Clinical Investigation Collaborative (PWS-CLIC) STUDYTRAX Clinical Database

The primary objective of the study is to improve the quality of clinical research and medical care for people with Prader-Willi syndrome (PWS) across the lifespan through collaborative investigation...

Clinicaltrials.gov ID: NA

Clinical Trial / Research Study

Inspiring New Science in Guiding Healthcare in Turner Syndrome (INSIGHTS) Registry

The overarching aim of this study is to establish a national, multicenter, prospective, longitudinal clinical data registry to improve clinical outcomes in individuals with Turner Syndrome (TS). This...

Clinicaltrials.gov ID: NCT05052606

Clinical Trial / Research Study

International Registries for Rare Conditions affecting Sex Development and Maturation (Endocrinology)

To learn more about this study, please email the study team member listed below.

Our Researchers

Endocrine Research Team

Participate in Research

Our researchers offer patients and families access to the latest medical studies, known as clinical trials, aimed at finding better ways to diagnose and treat childhood diseases. Family participation in our efforts helps this process.

Support Our Research

More than half of the kids who come to Seattle Children’s live with serious conditions that they will have for the rest of their lives. Research can give them a different future. Under designation, select “Other” and enter Clinical and Translational Research.

Contact Us

Endocrinology Research

For questions or inquiries, email: endocrineresearch@seattlechildrens.org

Physical Address

Center for Clinical and Translational Research
1920 Terry Ave.
Seattle, WA 98101