Michael J Bamshad, MD

Michael J Bamshad, MD

Specialties

  • Children's Title: Division Chief
  • Academic Title: Professor
  • Foundation Title: Allan and Phyllis Treuer Endowed Chair in Genetics and Development
  • Research Center: Center for Clinical and Translational Research
  • On Staff Since: January 2006

  • Biography

    Michael J. Bamshad, MD, is professor in the Department of Pediatrics and adjunct professor of genome sciences at the University of Washington. His laboratory addresses the origins and affinities of humans, develops novel strategies to find disease susceptibility variants and characterizes genetic variants influencing risk for an assortment of health-related conditions.

     Bamshad is particularly interested in identifying genetic variants that cause birth defects that alter risk for chronic diseases of childhood, infections and preterm birth, and that influence chemosensory perception such as taste.  His laboratory has identified genetic variants that underlie several disorders manifested by either limb defects or heart defects.  Bamshad’s lab has recently discovered that mutations in several genes (e.g., TNNI2, TNNT3, TPM2, MYH3) that encode proteins of the contractile apparatus of fast-twitch myofibers cause several syndromes characterized by contractures of the feet such as clubfoot.  Researchers in his lab are now trying both to understand the mechanism by which these mutations disrupt muscle function and also to determine whether these genes influence susceptibility to idiopathic clubfoot.

    Board Certification(s)

    Clinical Genetics and Genomics (MD)

    Education

    University of Missouri School of Medicine-Kansas City, Kansas City, MO
    University of Kansas at Lawrence, Lawrence, KS

    Residency

    University of Utah Medical Center, Salt Lake City, UT

    Fellowship

    University of Utah School of Medicine, Salt Lake City, UT

    Clinical Interests

    Genetic analysis of birth defects, especially limb and heart malformation disorders; genetic analysis of susceptibility to autoimmune disorders and infectious disease as well as human evolutionary biology.

    Research Description

    My laboratory addresses the origins and affinities of humans, develops novel strategies to find disease susceptibility variants and characterizes genetic variants influencing risk for an assortment of health-related conditions. I am particularly interested in identifying genetic variants that cause birth defects that alter risk for chronic diseases of childhood, infections and preterm birth, and that influence chemosensory perception such as taste.

    My laboratory has identified genetic variants that underlie several disorders manifested by either limb defects or heart defects. My lab recently discovered that mutations in several genes (e.g., TNNI2, TNNT3, TPM2, MYH3) that encode proteins of the contractile apparatus of fast-twitch myofibers cause several syndromes characterized by contractures of the feet such as clubfoot.

    Researchers in my lab are now trying both to understand the mechanism by which these mutations disrupt muscle function and also to determine whether these genes influence susceptibility to idiopathic clubfoot. Additionally, the development of a DNA core repository for future population studies is ongoing.

    Research Focus Area

    Genetics and Developmental Biology, Translational Research

  • Patient Testimonials

  • Awards and Honors

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  • Publications

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  • Presentations

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  • Research Funding

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